Characterization and Evaluation of Commercial Carboxymethyl Cellulose Potential as an Active Ingredient for Cosmetics

Carboxymethyl cellulose is the most used water-soluble with applications in industries such as food, cosmetics, and tissue engineering. However, due to a perceived lack of biological activity, carboxymethyl mostly structural element. As such, this work sought investigate whether CMC possesses relevant properties that could grant it added value cosmeceutical ingredient future skincare formulations. To end, samples (Mw between 471 322 kDa) skin cell cytotoxicity, impact upon pro-collagen I α production, inflammatory response were evaluated. Results showed not cytotoxic towards HaCat HDFa up 10 mg/mL while simultaneously promoting intracellular production by 228% relative basal metabolism, which appeared be related highest DS Mw. Additionally, modulated immune they decreased ca. 1.4-fold IL-8 increased IL-6 levels five fold. Despite increase, only two presented similar those inflammation control. Considering these results, potential more natural alternative traditional bioactive cosmetic ingredients and, capable being ingredient, may play key role